Detailed view for PVX_081575

Basic information

TDR Targets ID: 268777
Plasmodium vivax, hypothetical protein, conserved
Source Database / ID:  PlasmoDB 

pI: 10.0513 | Length (AA): 1378 | MW (Da): 155155 | Paralog Number: 0

Signal peptide: Y | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG4

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00270   DEAD/DEAH box helicase
PF00271   Helicase conserved C-terminal domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005524   ATP binding  
GO:0004386   helicase activity  
GO:0003676   nucleic acid binding  
GO:0008026   ATP-dependent helicase activity  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 10 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1103 1284 1t5i (A) 261 428 19.00 0 0.99 0.23 -0.92
1124 1255 1s2m (A) 271 386 33.00 0.0000008 0.96 0.45 -1.26
23 137 1w9r (A) 1 119 14.00 0.54 0 0.194254 -0.24
249 469 4gnk (E) 951 1188 13.00 0.91 0 0.276577 -0.35
292 415 4wij (A) 465 587 10.00 0.21 0 0.296185 -1.25
341 452 2fxo (A) 840 951 16.00 0.79 0.01 0.306477 -0.83
1117 1265 2zu6 (C) 257 385 28.00 0.00022 1 0.268328 0.13
1124 1255 1s2m (A) 271 386 33.00 0.0000032 1 0.322991 0.06
1205 1257 2rb4 (A) 391 449 42.00 0.024 0.11 0.203662 0.99
1275 1372 3ho3 (A) 330 422 31.00 0.2 0.06 0.151318 1.09

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile intraerythrocytic - 6 hs, intraerythrocytic - 12 hs, intraerythrocytic - 18 hs, intraerythrocytic - 24 hs. Zhu L
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile intraerythrocytic - 30 hs, intraerythrocytic - 36 hs, intraerythrocytic - 40 hs, intraerythrocytic - 48 hs. Zhu L
Show/Hide expression data references
  • Zhu L New insights into the Plasmodium vivax transcriptome using RNA-Seq.

Orthologs

Ortholog group members (OG5_155370)

Species Accession Gene Product
Plasmodium berghei PBANKA_0209500   ATP dependent RNA helicase, putative
Plasmodium falciparum PF3D7_0103600   ATP-dependent RNA helicase, putative
Plasmodium knowlesi PKNH_0209900   ATP-dependent RNA helicase, putative
Plasmodium vivax PVX_081575   hypothetical protein, conserved
Plasmodium yoelii PY04834   hypothetical protein
Theileria parva TP01_0212   hypothetical protein

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier PVX_081575 (Plasmodium vivax), hypothetical protein, conserved
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